How It Works: Botox Alternatives

Since its approval by the FDA for cosmetic use in 2002, Botox has enjoyed a huge rise in popularity among those seeking to reduce wrinkles and give their skin a more youthful appearance. Botox is a safer, injectable form of botulism toxin. Botox treatments work by blocking the nerve transmissions that cause facial muscles to contract, resulting in a temporary mild paralysis of the facial muscles where it is injected. The average procedure costs about $400-$500.

Many of the products on the market today designed to reduce wrinkles rely on ingredients that work similar to Botox: by limiting facial muscle contractions to allow skin to smoothen naturally. Instead of relying on expensive injections, many of the most popular products rely on topical ingredients that reduce nerve stimulation to the facial muscles. These ingredients, called hexapeptides, can produce results similar to Botox without the cost or hassle of visiting a dermatologist.

The most popular and effective products contain Acetyl Hexapeptide-3, a powerful non-toxic agent that can dramatically reduce fine lines and wrinkles around eyes, mouth, and forehead. In sufficient concentrations (at least 5%), Acetyl Hexapeptide-3 products can cause significant improvements in the youthful appearance of skin. When selecting an anti-wrinkle product, be sure to find one that contains a high concentration of Acetyl Hexapeptide-3, is hypoallergenic (if you have sensitive skin), and offers a guarantee of satisfaction.

Special thanks to the American Academy of Dermatology (AAD). Botox is a registered trademark of Allergan Labs.

Compare Skin Care Products

CategoryAvotoneStriVectinRejuvenexHydroderm
Success Rate90%80%60%60%
Price (3 months)$160.00$135.00$135.00$240.00
ReputationGreatExcellentFairGood
SupportGreatGreatGoodGreat
Guarantee60 days30 daysNone30 days
Shipping Time4 days6 days9 days5 days
Total Score94 pts91 pts86 pts79 pts
Data compiled from independent research, consumer reviews, and review staff analysis.

1. Avotone (Top Rated)

Our highest rating went to Avotone as the #1 anti-wrinkle skin cream. It contains 10% AH-3 to reduce fine lines and wrinkles and avocado oil to moisturize and replenish. It is safe for male and female users, and was reported to have a significant effect on wrinkles and skin texture in just 1-2 months of use. Shipping time and value were also rated highly by reviewers. $160.00 for 3 months supply.

2. StriVectin-SD

Originally designed to reduce the appearance of stretch marks, StriVectin has proven a popular facial cream to minimize the appearance of frown lines and wrinkles. It does contain an oligo-peptide that reviewers report helps with forehead lines and crow's feet. Users must use frequently or results fade quickly. $135.00 for 3 months supply.

3. Rejuvenex

One of the older products on the market, Rejuvenex blends Vitamin C and Alpha-hydroxy acid with plant extracts to produce an anti-aging skin cream. No effect on deep wrinkles was experienced after Rejuvenex use. It was reported to have effective sunscreen properties, but some users report mild redness with repeated use. $135.00 for 3 months supply.

Limitations: No money-back guarantee. Some users report skin irritation. Not effective for deep wrinkles.

4. Hydroderm

Hydroderm consists of marine collagen and Vyo-serum. It is supposed to allow collagen to absorb through the skin and strengthen the skin's own collagen. It is a liquid, applied twice daily to improve skin tone and firmness. Hydroderm is not recommended for male users. $240.00 for 3 month supply.

Considerations: Most expensive option reviewed. Not suitable for men. Limited to skin tone and firmness improvements.